TRIO Stream 1: Clinical Registries

Clinical registries and other data sources separately capture information concerning patient conditions, transfusion history, and clinical outcomes. Combining these data sources will assist in understanding transfusion outcomes and so inform clinical practice and health policy.

Several well-established registries exist for clinical conditions in which transfusion is a mainstay of therapy, including areas which account for a substantial proportion of transfusion episodes overall.  Information concerning transfusions received by individual patients is captured for non haematological operational purposes by a number of other databanks.  The opportunity exists to combine transfusion information from these sources to address important outstanding questions regarding transfusion outcomes.
Registries selected for interrogation and data linkage are:

We have identified important areas where clinical management depends on transfusion support, individuals require high volume transfusion support over long periods, and there is a lack of evidence to inform transfusion practice and policy. In several of these areas, small patient numbers, limited baseline information and clinical diversity render clinical trials impractical.

We are establishing new clinical registries for these diseases using methodologies developed by the Project Investigators. Information obtained through the new registries will not only inform clinical practice, for example through refinement of practice guidelines, but will be an important consideration in planning to ensure adequate provision of blood components and associated healthcare resources.

New Registries specifically developed through TRIO program:

  • Aplastic Anaemic
  • Another new clinical registry will be developed in 2011/12

If you would like more information or are interested in the participating in the Transfusion Research: Improving Outcomes Project please click here